Asynchronous globin chain synthesis in rabbit reticulocyte lystates induced
by hemin-controlled repressor
RS Franco, JW Hogg and OJ Martelo
To define further the role of hemin-controlled repressor (HCR) in globin
synthesis, we studied its effect on the synthesis of individual globin
chains in a rabbit reticulocyte lysate cell-free system. In the presence of
HCR there was a marked globin chain imbalance, resulting in a lowered
alpha/beta ratio. These findings in vitro may have relevance to certain
clinical heme deficiency states in which a similar globin chain imbalance
has been observed.
Volume 51,
Issue 4,
pp. 653-658,
04/01/1978
Copyright © 1978 by The American Society of Hematology