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Three-dimensional model of bone marrow
N Mohandas and M Prenant
Three-dimensional scale models of bone marrow from a hypertransfused and a
normal rat were constructed. The model of marrow from the hypertransfused
rat demonstrated the existence of distinct erythroblastic islands in situ
in which the erythroblasts underwent sychronous maturation. Macrophages
were found in close association with the developing erythroblasts. The
immature erythroblasts were tightly grouped, but as they matured they began
to move apart. Erythroblasts in individual clusters were found to be at the
same stage of morphologic maturation. In contrast, the model of marrow from
the normal rat showed a majority of clusters containing erythroblasts at
various stages of maturation. Erythropoiesis was not spatially restricted
to the area proximal to the sinuses but was found to occur over the entire
marrow space. Thrombopoiesis, however, was found to take place exclusively
in the immediate vicinity of the marrow sinuses.
Volume 51,
Issue 4,
pp. 633-643,
04/01/1978
Copyright © 1978 by The American Society of Hematology
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