Acute leukemia with Burkitt's tumor cells: A study of six cases with
special reference to lymphocyte surface markers
G Flandrin, JC Brouet, MT Daniel and JL Preud'homme
In six patients with acute leukemia (about 2% of the patients referred for
acute lymphoblastic leukemia) the blast cells invading bone marrow and
blood showed all the cytologic, cytochemical, and electron microscopy
features of Burkitt's tumor cells. The presence of monoclonal surface
immunoglobulins (their synthesis being proved by in vitro culture
experiments), the binding of IgG aggregates, and the absence of rosette
formation with sheep red cells documented the monoclonal B-cell origin of
these blast cells which is in sharp contrast to the findings in common
acute lymphoblastic leukemia. The course of the disease was usually rapidly
fatal without chemotherapy- induced remission.
Volume 45,
Issue 2,
pp. 183-188,
02/01/1975
Copyright © 1975 by The American Society of Hematology
