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Blood, 15 July 2006, Vol. 108, No. 2, pp. 501-509. Prepublished online as a Blood First Edition Paper on March 21, 2006; DOI 10.1182/blood-2005-10-4209. This Article Full Text (PDF) Supplemental Tables All Versions of this Article: 2005-10-4209v1 108/2/501    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Gribi, R. Articles by Medvinsky, A. Search for Related Content PubMed PubMed Citation Articles by Gribi, R. Articles by Medvinsky, A. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted October 24, 2005 Accepted March 4, 2006 The differentiation programme of embryonic definitive hematopoietic stem cells is largely 4 integrin independent Ruby Gribi, Lilian Hook, Janice Ure, and Alexander Medvinsky* MRC Centre Development in Stem Cell Biology, Institute for Stem Cell Research, University of Edinburgh, Edinburgh, Scotland, United Kingdom * Corresponding author; email: a.medvinsky{at}ed.ac.uk. Previous analyses of the roles of 4 integrins in hematopoiesis by other groups have led to conflicting evidence. 4 integrin mutant cells developing in [4 integrin-/-: wt] chimeric mice are not capable of completing lymphomyeloid differentiation (Arroyo et al., 1996, 1999), whereas conditional inactivation of 4 integrin in adult mice has only subtle effects (Scott et al, 2003). We show here that circumventing the fetal stage of hematopoietic stem cell (HSC) development by transplantation of embryonic 4 integrin-/- cells into the adult microenvironment results in robust and stable long-term generation of 4 integrin null lymphoid and myeloid cells, although colonization of Peyer's patches and the peritoneal cavity is significantly impaired. We argue here that collectively, our data and the data from other groups suggest a specific requirement for 4 integrin during the fetal/neonatal stages of HSC development that is essential for normal execution of the lymphomyeloid differentiation programme. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: H. Qian, E. Georges-Labouesse, A. Nystrom, A. Domogatskaya, K. Tryggvason, S. E. W. Jacobsen, and M. Ekblom Distinct roles of integrins {alpha}6 and {alpha}4 in homing of fetal liver hematopoietic stem and progenitor cells Blood, October 1, 2007; 110(7): 2399 - 2407. [Abstract] [Full Text] [PDF] S. Gottschling, R. Saffrich, A. Seckinger, U. Krause, K. Horsch, K. Miesala, and A. D. Ho Human Mesenchymal Stromal Cells Regulate Initial Self-Renewing Divisions of Hematopoietic Progenitor Cells by a {beta}1-Integrin-Dependent Mechanism Stem Cells, March 1, 2007; 25(3): 798 - 806. [Abstract] [Full Text] [PDF] B. M. Zeigler, D. Sugiyama, M. Chen, Y. Guo, K. M. Downs, and N. A. Speck The allantois and chorion, when isolated before circulation or chorio-allantoic fusion, have hematopoietic potential Development, November 1, 2006; 133(21): 4183 - 4192. [Abstract] [Full Text] [PDF] G. Bungartz, S. Stiller, M. Bauer, W. Muller, A. Schippers, N. Wagner, R. Fassler, and C. Brakebusch Adult murine hematopoiesis can proceed without beta1 and beta7 integrins Blood, September 15, 2006; 108(6): 1857 - 1864. [Abstract] [Full Text] [PDF]

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