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Blood, 1 January 2006, Vol. 107, No. 1, pp. 187-189. Prepublished online as a Blood First Edition Paper on August 25, 2005; DOI 10.1182/blood-2005-07-3059. This Article Full Text (PDF) All Versions of this Article: 2005-07-3059v1 107/1/187    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Zimring, J. C Articles by Horan, J. T Search for Related Content PubMed PubMed Citation Articles by Zimring, J. C Articles by Horan, J. T Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted July 29, 2005 Accepted August 18, 2005 Immunization to minor histocompatibility antigens on transfused RBC through crosspriming into recipient MHC class I pathways James C Zimring*, Gregory A Hair, Seema S Deshpande, and John T Horan Transfusion Medicine Program, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA Department of Pediatrics, Emory University School of Medicine, AFLAC Center for Pediatric Blood and Cancer Disorders, Atlanta, GA, USA * Corresponding author; email: jzimrin{at}emory.edu. Increased rates of bone marrow transplant (BMT) graft rejection are observed in patients whose illnesses necessitate chronic transfusion prior to BMT, such as sickle cell disease, thalassemia, or aplastic anemia. Because BMTs in this setting are routinely HLA matched, any immunization responsible for increased rejection is likely against minor histocompatibility antigens (mHAs). It has been assumed that contaminating leukocytes in red blood cell (RBC) units are the main source of immunization to mHAs. However, in this report we demonstrate that antigens on donor RBC are presented in the MHC class I pathway of recipient antigen presenting cells, resulting in activation and expansion of recipient CD8+ T cells specific for donor mHAs. Since human hematopoietic progenitor cells express many of the known mHAs, this observation provides a mechanism by which chronic transfusion of even stringently leukoreduced RBC may result in sufficient mHA immunization to increase the frequency of BMT rejection. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Transfusion tickles T cells through cross-priming James D. Gorham Blood 2006 107: 6-7. [Full Text] [PDF]

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