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Blood, 1 January 2006, Vol. 107, No. 1, pp. 404-409. Prepublished online as a Blood First Edition Paper on September 8, 2005; DOI 10.1182/blood-2005-07-3045. This Article Full Text (PDF) All Versions of this Article: 2005-07-3045v1 107/1/404    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Matsuoka, K.-i. Articles by Teshima, T. Search for Related Content PubMed PubMed Citation Articles by Matsuoka, K.-i. Articles by Teshima, T. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted July 29, 2005 Accepted August 26, 2005 Fetal tolerance to maternal antigens improves the outcome of allogeneic bone marrow transplantation by a CD4+CD25+ T cell-dependent mechanism Ken-ichi Matsuoka, Tatsuo Ichinohe, Daigo Hashimoto, Shoji Asakura, Mitsune Tanimoto, and Takanori Teshima* Biopathological Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan Department of Hematology/Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan * Corresponding author; email: tteshima{at}cancer.med.kyushu-u.ac.jp. The lack of donor availability is a major limitation to the widespread use of allogeneic hematopoietic stem cell transplantation and therefore it would be beneficial to identify less immunogenic HLA mismatches. The maternal and fetal antigens which are transmitted through the bi-directional transplacental passage during pregnancy may induce tolerance to noninherited maternal antigens (NIMAs) in offspring and to inherited paternal antigens (IPAs) in the mother. Using mouse models of bone marrow transplantation (BMT), we found that a "child-to-mother" BMT from a NIMA-exposed donor reduced the morbidity and mortality of graft-versus-host disease in an antigen-specific manner, however, a "mother-to-child" BMT from an IPA-exposed donor did not. The NIMA-complementary BMT preserved the graft-versus-leukemia effects and favored the immune reconstitution, thus resulting in a marked improvement of the outcome after BMT. These tolerogenic NIMA effects were completely abolished by the depletion of CD4+CD25+ cells from the donor inoculums, thus suggesting the involvement of CD4+CD25+ regulatory T cells in the tolerogenic NIMA effects. Our findings may therefore have profound implications on the performance of clinical BMT while also potentially helping to develop new strategies for using a NIMA-mismatched donor in the absence of a HLA-identical donor. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: You will never forget your mother! Johannes J. van Rood Blood 2006 107: 7-8. [Full Text] [PDF] This article has been cited by other articles: M.-C. Maurel and C. Kanellopoulos-Langevin Heredity--Venturing Beyond Genetics Biol Reprod, July 1, 2008; 79(1): 2 - 8. [Abstract] [Full Text] [PDF] M. L. Molitor-Dart, J. Andrassy, J. Kwun, H. A. Kayaoglu, D. A. Roenneburg, L. D. Haynes, J. R. Torrealba, J. L. Bobadilla, H. W. Sollinger, S. J. Knechtle, et al. Developmental Exposure to Noninherited Maternal Antigens Induces CD4+ T Regulatory Cells: Relevance to Mechanism of Heart Allograft Tolerance J. Immunol., November 15, 2007; 179(10): 6749 - 6761. [Abstract] [Full Text] [PDF] Y. Sakoda, D. Hashimoto, S. Asakura, K. Takeuchi, M. Harada, M. Tanimoto, and T. Teshima Donor-derived thymic-dependent T cells cause chronic graft-versus-host disease Blood, February 15, 2007; 109(4): 1756 - 1764. [Abstract] [Full Text] [PDF]

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