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Blood, 1 January 2006, Vol. 107, No. 1, pp. 265-276. Prepublished online as a Blood First Edition Paper on September 8, 2005; DOI 10.1182/blood-2005-06-2508. This Article Full Text (PDF) All Versions of this Article: 2005-06-2508v1 107/1/265    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Morton, L. M Articles by Linet, M. S Search for Related Content PubMed PubMed Citation Articles by Morton, L. M Articles by Linet, M. S Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted June 24, 2005 Accepted August 26, 2005 Lymphoma incidence patterns by WHO subtype in the United States, 1992-2001 Lindsay M Morton*, Sophia S Wang, Susan S Devesa, Patricia Hartge, Dennis D Weisenburger, and Martha S Linet Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD, USA Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA * Corresponding author; email: mortonli{at}mail.nih.gov. Because the causes of most lymphoid neoplasms remain unknown, comparison of incidence patterns by disease subtype may provide critical clues for future etiologic investigations. We therefore conducted a comprehensive assessment of 114,548 lymphoid neoplasms diagnosed during 1992-2001 in 12 SEER registries according to the internationally-recognized WHO lymphoma classification introduced in 2001. Cases coded in ICD-O-2 were converted to ICD-O-3 for WHO subtype assignment. Age-specific and age-adjusted rates were compared by sex and race (white, black, Asian). Age-adjusted trends in incidence were estimated by sex and race using weighted least-squares log-linear regression. Diverse incidence patterns and trends were observed by lymphoid neoplasm subtype and population. In the elderly (75+ years), rates of DLBCL and follicular lymphoma increased 1.4% and 1.8% per year, respectively, whereas rates of CLL/SLL declined 2.1% per year. Although whites bear the highest incidence burden for most lymphoid neoplasm subtypes, most notably for hairy cell leukemia and follicular lymphoma, black predominance was observed for plasma cell and T-cell neoplasms. Asians have considerably lower rates than whites and blacks for CLL/SLL and Hodgkin lymphoma. We conclude that the striking differences in incidence patterns by histologic subtype strongly suggest that there is etiologic heterogeneity among lymphoid neoplasms, and support the pursuit of epidemiologic analysis by subtype. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: L. Schapira, T. J. Moynihan, C. F. von Gunten, and T. J. Smith Phase I Versus Palliative Care: Striking the Right Balance J. Clin. Oncol., January 10, 2009; 27(2): 307 - 308. [Full Text] [PDF] L. M. Morton, S. S. Wang, W. Cozen, M. S. Linet, N. Chatterjee, S. Davis, R. K. Severson, J. S. Colt, M. A. Vasef, N. Rothman, et al. Etiologic heterogeneity among non-Hodgkin lymphoma subtypes Blood, December 15, 2008; 112(13): 5150 - 5160. [Abstract] [Full Text] [PDF] R. Wang, Y. Zhang, Q. Lan, T. R. Holford, B. Leaderer, S. Hoar Zahm, P. Boyle, M. Dosemeci, N. Rothman, Y. Zhu, et al. 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