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Blood, 15 September 2005, Vol. 106, No. 6, pp. 2076-2082. Prepublished online as a Blood First Edition Paper on June 7, 2005; DOI 10.1182/blood-2004-12-4802. This Article Full Text (PDF) All Versions of this Article: 2004-12-4802v1 106/6/2076    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Fuchs, A. Articles by Colonna, M. Search for Related Content PubMed PubMed Citation Articles by Fuchs, A. Articles by Colonna, M. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted December 16, 2004 Accepted May 22, 2005 Paradoxical inhibition of human natural interferon-producing cells by the activating receptor NKp44 Anja Fuchs, Marina Cella, Takayuki Kondo, and Marco Colonna* Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA Department of Clinical Research, Nagasaki Medical Center of Neurology, Nagasaki, Japan * Corresponding author; email: mcolonna{at}pathology.wustl.edu. NK cell-mediated cytoxicity is triggered by multiple activating receptors associated with the signaling adaptor protein DAP12/KARAP. Here we show that one of these receptors, NKp44, is present on a subset of natural interferon-producing cells (IPC) in tonsils. NKp44 expression can also be induced on blood IPC after in vitro culture with IL-3. Cross-linking of NKp44 does not trigger IPC-mediated cytotoxicity, but, paradoxically, inhibits IFN- production by IPC in response to CpG oligonucleotides. We find that IPC in tonsils are in close contact with CD8+ T cells and demonstrate that a subset of memory CD8+ T cells produces IL-3. Therefore, IL-3-mediated induction of NKp44 on IPC may be an important component of the ongoing cross talk between the innate and adaptive immune response that allows memory CD8+ T cells to control the IPC response to virus. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: L.-H. Tai, M.-L. Goulet, S. Belanger, N. Toyama-Sorimachi, N. Fodil-Cornu, S. M. Vidal, A. D. Troke, D. W. McVicar, and A. P. Makrigiannis Positive regulation of plasmacytoid dendritic cell function via Ly49Q recognition of class I MHC J. Exp. Med., December 22, 2008; 205(13): 3187 - 3199. [Abstract] [Full Text] [PDF] X. Ju, M. Zenke, D. N. J. 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Gross, P. Attal, A. Ben Yaakov, D. Goldman-Wohl, B. Maly, N. Stern, G. Katz, R. Gazit, et al. A phenotypic and functional characterization of NK cells in adenoids J. Leukoc. Biol., November 1, 2007; 82(5): 1095 - 1105. [Abstract] [Full Text] [PDF] E. Martinelli, C. Cicala, D. Van Ryk, D. J. Goode, K. Macleod, J. Arthos, and A. S. Fauci HIV-1 gp120 inhibits TLR9-mediated activation and IFN-{alpha} secretion in plasmacytoid dendritic cells PNAS, February 27, 2007; 104(9): 3396 - 3401. [Abstract] [Full Text] [PDF] M. D. Chiesa, C. Romagnani, A. Thiel, L. Moretta, and A. Moretta Multidirectional interactions are bridging human NK cells with plasmacytoid and monocyte-derived dendritic cells during innate immune responses Blood, December 1, 2006; 108(12): 3851 - 3858. [Abstract] [Full Text] [PDF] H. Sjolin, S. H. Robbins, G. Bessou, A. Hidmark, E. Tomasello, M. Johansson, H. Hall, F. Charifi, G. B. K. Hedestam, C. A. Biron, et al. 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