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Blood, 1 April 2004, Vol. 103, No. 7, pp. 2771-2778. Prepublished online as a Blood First Edition Paper on December 18, 2003; DOI 10.1182/blood-2003-09-3243. This Article Full Text (PDF) Supplemental Table All Versions of this Article: 2003-09-3243v1 103/7/2771    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Chiaretti, S. Articles by Foa, R. Search for Related Content PubMed PubMed Citation Articles by Chiaretti, S. Articles by Foa, R. Related Collections Related Article in Blood Online Social Bookmarking                   What's this? Submitted September 23, 2003 Accepted November 20, 2003 Gene expression profile of adult T-cell acute lymphocyitc leukemia identifies distinct subsets of patients with different response to therapy and survival Sabina Chiaretti, Xiaochun Li, Robert Gentleman, Antonella Vitale, Marco Vignetti, Franco Mandelli, Jerome Ritz*, and Robin Foa Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA Department of Biostatistical Science, Dana Farber Cancer Institute, Boston, MA, USA Dipartimento di Biotecnologie Cellulari ed Ematologia, University La Sapienza, Rome, Italy * Corresponding author; email: jerome_ritz{at}dfci.harvard.edu. Gene expression profiles were examined in 33 adult patients with T-cell acute lymphocytic leukemia (T-ALL). Non-specific filtering criteria identified 313 genes differentially expressed in the leukemic cells. Hierarchical clustering of samples identified two groups that reflected the degree of T-cell differentiation, but was not associated with clinical outcome. Comparison between refractory patients and those who responded to induction chemotherapy identified a single gene, IL-8, that was highly expressed in refractory T-ALL cells and a set of 30 genes that were highly expressed in leukemic cells from patients who achieved complete remission. We next identified 19 genes that were differentially expressed in T-ALL cells from patients who either relapsed or remained in continuous complete remission. A model based on the expression of 3 of these genes was predictive of duration of remission. The 3-gene model was validated on a further set of T-ALL samples from 18 additional patients treated on the same clinical protocol. This study demonstrates that gene expression profiling can identify a limited number of genes that are predictive of response to induction therapy and remission duration in adult T-ALL. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Adults are not simply big children Peter D. Aplan Blood 2004 103: 2437-2438. [Full Text] [PDF] This article has been cited by other articles: E. Flex, V. Petrangeli, L. Stella, S. Chiaretti, T. Hornakova, L. Knoops, C. Ariola, V. Fodale, E. Clappier, F. Paoloni, et al. Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia J. Exp. Med., April 14, 2008; 205(4): 751 - 758. [Abstract] [Full Text] [PDF] M. Mitsuhashi, K. Endo, K. Obara, H. Izutsu, T. Ishida, N. Chikatsu, and A. Shinagawa Ex Vivo Simulation of the Action of Antileukemia Drugs by Measuring Apoptosis-Related mRNA in Blood Clin. Chem., April 1, 2008; 54(4): 673 - 681. [Abstract] [Full Text] [PDF] M. T. 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