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Prepublished online as a Blood First Edition Paper on January 2, 2003; DOI 10.1182/blood-2002-10-3063. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-10-3063v1 101/9/3520    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Fonteneau, J.-F. Articles by Bhardwaj, N. Search for Related Content PubMed PubMed Citation Articles by Fonteneau, J.-F. Articles by Bhardwaj, N. Related Collections Immunobiology Immunotherapy Chemokines, Cytokines, and Interleukins Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 May 2003, Vol. 101, No. 9, pp. 3520-3526 IMMUNOBIOLOGY Activation of influenza virus-specific CD4+ and CD8+ T cells: a new role for plasmacytoid dendritic cells in adaptive immunity Jean-François Fonteneau, Michel Gilliet, Marie Larsson, Ida Dasilva, Christian Münz, Yong-Jun Liu, and Nina Bhardwaj From the Laboratory of Molecular Neuro-Oncology, and the Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY; and the Department of Immunology, DNAX Research Institute, Palo Alto, CA. Plasmacytoid dendritic cells (pDCs) contribute to innate antiviral immune responses by producing type I interferons (IFNs) upon exposure to enveloped viruses. However, their role in adaptive immune responses, such as the initiation of antiviral T-cell responses, is not known. In this study, we examined interactions between blood pDCs and influenza virus with special attention to the capacity of pDCs to activate influenza-specific T cells. pDCs were compared with CD11c+ DCs, the most potent antigen-presenting cells (APCs), for their capacity to activate T-cell responses. We found that like CD11c+ DCs, pDCs mature following exposure to influenza virus, express CCR7, and produce proinflammatory chemokines, but differ in that they produce type I IFN and are resistant to the cytopathic effect of the infection. After influenza virus exposure, both DC types exhibited an equivalent efficiency to expand anti-influenza virus cytotoxic T lymphocytes (CTLs) and T helper 1 (TH1) CD4+ T cells. 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