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Figure 2.
Structure of the Bcr protein.
Note the dimerization domain (DD) and the 2 cyclic adenosine
monophosphate kinase homologous domains at the N terminus. Y177 is the
autophosphorylation site crucial for binding to Grb-2. The center of
the molecule contains a region homologous to Rho guanidine nucleotide
exchange factors (Rho-GEF) as well as dbl-like and pleckstrin homology
(PH) domains. Toward the C-terminus a putative site for
calcium-dependent lipid binding (CaLB) and a domain with activating
function for Rac-GTPase (Rac-GAP) are found. Arrowheads indicate the
position of the breakpoints in the BCR-ABL fusion
proteins.
