|
|
Blood, Vol. 107, Issue 6, 2536-2539, March 15, 2006
Classical Hodgkin lymphoma is characterized by high constitutive expression of activating transcription factor 3 (ATF3), which promotes viability of Hodgkin/Reed-Sternberg cells
Blood Janz et al.
107: 2536
Supplemental materials for: Janz et al
Files in this Data Supplement:
- Figure S1. Hierarchical clustering discriminates Hodgkin and non-Hodgkin B cell lines (JPG, 410 KB)
-
Gene expression profiles of the indicated cell lines were generated using Affymetrix U95A oligonucleotide microarrays. Hierarchical clustering analysis was performed with the Cluster and TreeView software. (A) HRS cell lines (KM-H2, L428, L1236, L591) were separated from non-Hodgkin B cell lines in one main branch of the dendrogram. Within the group of non-Hodgkin cell lines, the plasma cell lines (U266, INA-6, MM.1S, L363) were divided from the pre-B cell line Reh and the Burkitt lymphoma cell lines Namalwa and BL60. (B) Expanded view of the cluster that most clearly separates between HRS and non-Hodgkin cells. Relative ATF3 expression across Hodgkin and non-Hodgkin cell lines is indicated (*).
|
|
