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Blood, 1 November 2006, Vol. 108, No. 9, pp. 2893-2896. Prepublished online as a Blood First Edition Paper on July 13, 2006; DOI 10.1182/blood-2006-04-016600. This Article Full Text (PDF) All Versions of this Article: blood-2006-04-016600v1 108/9/2893    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ogawa, M. Articles by Drake, C. J. Search for Related Content PubMed PubMed Citation Articles by Ogawa, M. Articles by Drake, C. J. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted April 11, 2006 Accepted June 27, 2006 Hematopoietic origin of fibroblasts/myofibroblasts: its patho-physiological implications Makio Ogawa*, Amanda C. LaRue, and Christopher J. Drake Ralph H. Johnson VA Medical Center, Medical Universtiy of South Carolina Medical Uniiversity of South Carolina * Corresponding author; email: ogawam{at}musc.edu. Tissue fibroblasts/ myofibroblasts play a key role in growth factor secretion, matrix deposition and matrix degradation and therefore are important in many pathological processes. Regarding the origin of tissue fibroblasts/myofibroblasts, a number of recent in vivo transplantation studies have suggested the bone marrow as the source of fibroblasts/myofibroblasts in liver, intestine, skin and lung. Because bone marrow cells are thought to contain two types of stem cells, i.e. hematopoietic stem cells (HSCs) and mesenchymal stem cells, it is important to determine which type of stem cells is the source of fibroblasts/myofibroblasts. To address this issue, we have carried out a series of studies of tissue reconstitution by single HSCs. By transplanting clones derived from single HSCs expressing transgenic enhanced green fluorescent protein, we found that fibroblasts/myofibroblasts in many organs and tissues are derived from HSCs. This brief note summarizes these findings and discusses clinical and experimental perspectives generated by this newly identified differentiation pathway of HSCs. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: E. Miyata, M. Masuya, S. Yoshida, S. Nakamura, K. Kato, Y. Sugimoto, T. Shibasaki, K. Yamamura, K. Ohishi, K. Nishii, et al. Hematopoietic origin of hepatic stellate cells in the adult liver Blood, February 15, 2008; 111(4): 2427 - 2435. [Abstract] [Full Text] [PDF] S. J. Salipante, J. M. Thompson, and M. S. Horwitz Phylogenetic Fate Mapping: Theoretical and Experimental Studies Applied to the Development of Mouse Fibroblasts Genetics, February 1, 2008; 178(2): 967 - 977. [Abstract] [Full Text] [PDF] J. Fujita, M. Mori, H. Kawada, Y. Ieda, M. Tsuma, Y. Matsuzaki, H. Kawaguchi, T. Yagi, S. Yuasa, J. Endo, et al. Administration of Granulocyte Colony-Stimulating Factor After Myocardial Infarction Enhances the Recruitment of Hematopoietic Stem Cell-Derived Myofibroblasts and Contributes to Cardiac Repair Stem Cells, November 1, 2007; 25(11): 2750 - 2759. [Abstract] [Full Text] [PDF] S. Swaminathan and S. V. Shah New Insights into Nephrogenic Systemic Fibrosis J. Am. Soc. Nephrol., October 1, 2007; 18(10): 2636 - 2643. [Abstract] [Full Text] [PDF]

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