|
|
 Previous Article | Table of Contents | Next Article 
Blood, Vol. 96 No. 1 (July 1), 2000:
pp. 210-217
Interferon- and - inhibit the in vitro differentiation of
immunocompetent human dendritic cells from CD14+ precursors
Bradford L. McRae,
Taro Nagai,
Roshanak Tolouei Semnani,
Jean Maguire van Seventer, and
Gijs A. van Seventer
From the Committee on Immunology, Department of Pathology, Division
of Biological Science, University of Chicago, Chicago, IL; BASF
Bioresearch, Worcester, MA; and Tsukiyono Hospital, Gunma, Japan.
Dendritic cell (DC) precursors and immature DC reside in epithelium
where they encounter pathogens and cytokines, which stimulate their
differentiation. We hypothesized that type-I interferons (IFN- and
- ), cytokines that are produced early in the innate immune response
against viruses and some bacteria, may influence DC differentiation and
function. To examine this possibility, we used an in vitro model of DC
differentiation in which initial culture of human CD14+
monocytes with granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin (IL)-4 generates immature DC, and subsequent culture with tumor necrosis factor (TNF)- drives the final
development into mature DC. We found in this model that IFN-/,
added from the initiation of the culture on, significantly reduced the
survival and altered the morphology and differentiation of DC.
TNF--dependent maturation of IFN--treated immature DC led to
cells with reduced expression of CD1a, CD40, CD54, and CD80 when
compared with mature DC controls. IFN-/-treated DC further had a
reduced capacity to induce naive Th-cell proliferation through
allostimulation or anti-CD3 monoclonal antibody stimulation. In
addition, IFN-/-treated DC secreted less IL-12 upon stimulation
with Staphylococcus aureus Cowan strain or with
CD4+ T cells, and this decrease correlated directly with
their inability to support CD4+ T-cell secretion of
IFN- , even though T-cell lymphotoxin production was unaffected.
These findings indicate that type-I IFNs can influence the generation
of acquired immune responses by modifying T-helper cell differentiation
through the regulation of DC differentiation and function.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
G. Gerlini, G. Mariotti, A. Chiarugi, P. Di Gennaro, R. Caporale, A. Parenti, L. Cavone, A. Tun-Kyi, F. Prignano, R. Saccardi, et al.
Induction of CD83+CD14+ Nondendritic Antigen-Presenting Cells by Exposure of Monocytes to IFN-{alpha}
J. Immunol.,
September 1, 2008;
181(5):
2999 - 3008.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Bochtler, A. Kroger, R. Schirmbeck, and J. Reimann
Type I IFN-Induced, NKT Cell-Mediated Negative Control of CD8 T Cell Priming by Dendritic Cells
J. Immunol.,
August 1, 2008;
181(3):
1633 - 1643.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. A. Gujar, A. K. Jenkins, C. S. Guy, J. Wang, and T. I. Michalak
Aberrant Lymphocyte Activation Precedes Delayed Virus-Specific T-Cell Response after both Primary Infection and Secondary Exposure to Hepadnavirus in the Woodchuck Model of Hepatitis B Virus Infection
J. Virol.,
July 15, 2008;
82(14):
6992 - 7008.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Zeng, H. Li, Y. Liu, Z. Zhang, Y. Zhang, and R. Yang
Tumor-Induced Suppressor of Cytokine Signaling 3 Inhibits Toll-like Receptor 3 Signaling in Dendritic Cells via Binding to Tyrosine Kinase 2
Cancer Res.,
July 1, 2008;
68(13):
5397 - 5404.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Marin-Esteban, M. Abdul, D. Charron, A. Haziot, and N. Mooney
Dendritic Cells Differentiated in the Presence of a Single-Stranded Viral RNA Sequence Conserve Their Ability To Activate CD4 T Lymphocytes but Lose Their Capacity for Th1 Polarization
Clin. Vaccine Immunol.,
June 1, 2008;
15(6):
954 - 962.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. F. Zhang, K. Okuma, R. Tanaka, A. Kodama, K. Kondo, A. A. Ansari, and Y. Tanaka
Generation of Mature Dendritic Cells with Unique Phenotype and Function by In Vitro Short-Term Culture of Human Monocytes in the Presence of Interleukin-4 and Interferon-{beta}
Experimental Biology and Medicine,
June 1, 2008;
233(6):
721 - 731.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Geyeregger, M. Zeyda, W. Bauer, E. Kriehuber, M. D. Saemann, G. J. Zlabinger, D. Maurer, and T. M. Stulnig
Liver X receptors regulate dendritic cell phenotype and function through blocked induction of the actin-bundling protein fascin
Blood,
May 15, 2007;
109(10):
4288 - 4295.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W-H Zhu, C-Z Lu, Y-M Huang, H Link, and B-G Xiao
A putative mechanism on remission of multiple sclerosis during pregnancy: estrogen-induced indoleamine 2,3-dioxygenase by dendritic cells
Multiple Sclerosis,
January 1, 2007;
13(1):
33 - 40.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. Dauer, K. Schad, J. Junkmann, C. Bauer, J. Herten, R. Kiefl, M. Schnurr, S. Endres, and A. Eigler
IFN-{alpha} promotes definitive maturation of dendritic cells generated by short-term culture of monocytes with GM-CSF and IL-4
J. Leukoc. Biol.,
August 1, 2006;
80(2):
278 - 286.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Dikopoulos, A. Bertoletti, A. Kroger, H. Hauser, R. Schirmbeck, and J. Reimann
Type I IFN Negatively Regulates CD8+ T Cell Responses through IL-10-Producing CD4+ T Regulatory 1 Cells
J. Immunol.,
January 1, 2005;
174(1):
99 - 109.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. C. Gauzzi, C. Purificato, K. Donato, Y. Jin, L. Wang, K. C. Daniel, A. A. Maghazachi, F. Belardelli, L. Adorini, and S. Gessani
Suppressive Effect of 1{alpha},25-Dihydroxyvitamin D3 on Type I IFN-Mediated Monocyte Differentiation into Dendritic Cells: Impairment of Functional Activities and Chemotaxis
J. Immunol.,
January 1, 2005;
174(1):
270 - 276.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Carbonneil, H. Saidi, V. Donkova-Petrini, and L. Weiss
Dendritic cells generated in the presence of interferon-{alpha} stimulate allogeneic CD4+ T-cell proliferation: modulation by autocrine IL-10, enhanced T-cell apoptosis and T regulatory type 1 cells
Int. Immunol.,
July 1, 2004;
16(7):
1037 - 1052.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Ichikawa, S. Hida, Y. Omatsu, S. Shimoyama, K. Takahara, S. Miyagawa, K. Inaba, and S. Taki
Defective development of splenic and epidermal CD4+ dendritic cells in mice deficient for IFN regulatory factor-2
PNAS,
March 16, 2004;
101(11):
3909 - 3914.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Della Bella, S. Nicola, A. Riva, M. Biasin, M. Clerici, and M. L. Villa
Functional repertoire of dendritic cells generated in granulocyte macrophage-colony stimulating factor and interferon-{alpha}
J. Leukoc. Biol.,
January 1, 2004;
75(1):
106 - 116.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Mohty, A. Vialle-Castellano, J. A. Nunes, D. Isnardon, D. Olive, and B. Gaugler
IFN-{alpha} Skews Monocyte Differentiation into Toll-Like Receptor 7-Expressing Dendritic Cells with Potent Functional Activities
J. Immunol.,
October 1, 2003;
171(7):
3385 - 3393.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Chaussabel, R. T. Semnani, M. A. McDowell, D. Sacks, A. Sher, and T. B. Nutman
Unique gene expression profiles of human macrophages and dendritic cells to phylogenetically distinct parasites
Blood,
July 15, 2003;
102(2):
672 - 681.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Moschella, B. Bisikirska, A. Maffei, K. P. Papadopoulos, D. Skerrett, Z. Liu, C. S. Hesdorffer, and P. E. Harris
Gene Expression Profiling and Functional Activity of Human Dendritic Cells Induced with IFN-{alpha}-2b: Implications for Cancer Immunotherapy
Clin. Cancer Res.,
June 1, 2003;
9(6):
2022 - 2031.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H.-R. Jiang, E. Muckersie, M. Robertson, and J. V. Forrester
Antigen-Specific Inhibition of Experimental Autoimmune Uveoretinitis by Bone Marrow-Derived Immature Dendritic Cells
Invest. Ophthalmol. Vis. Sci.,
April 1, 2003;
44(4):
1598 - 1607.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Krug, S. Rothenfusser, S. Selinger, C. Bock, M. Kerkmann, J. Battiany, A. Sarris, T. Giese, D. Speiser, S. Endres, et al.
CpG-A Oligonucleotides Induce a Monocyte-Derived Dendritic Cell-Like Phenotype That Preferentially Activates CD8 T Cells
J. Immunol.,
April 1, 2003;
170(7):
3468 - 3477.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. C. Gauzzi, I. Canini, P. Eid, F. Belardelli, and S. Gessani
Loss of Type I IFN Receptors and Impaired IFN Responsiveness During Terminal Maturation of Monocyte-Derived Human Dendritic Cells
J. Immunol.,
September 15, 2002;
169(6):
3038 - 3045.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. McDowell, M. Marovich, R. Lira, M. Braun, and D. Sacks
Leishmania Priming of Human Dendritic Cells for CD40 Ligand-Induced Interleukin-12p70 Secretion Is Strain and Species Dependent
Infect. Immun.,
August 1, 2002;
70(8):
3994 - 4001.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Forman, R. M. Welsh, T. G. Markees, B. A. Woda, J. P. Mordes, A. A. Rossini, and D. L. Greiner
Viral Abrogation of Stem Cell Transplantation Tolerance Causes Graft Rejection and Host Death by Different Mechanisms
J. Immunol.,
June 15, 2002;
168(12):
6047 - 6056.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Montoya, G. Schiavoni, F. Mattei, I. Gresser, F. Belardelli, P. Borrow, and D. F. Tough
Type I interferons produced by dendritic cells promote their phenotypic and functional activation
Blood,
May 1, 2002;
99(9):
3263 - 3271.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. D. Saemann, O. Parolini, G. A. Bohmig, P. Kelemen, P.-M. Krieger, J. Neumuller, K. Knarr, W. Kammlander, W. H. Horl, C. Diakos, et al.
Bacterial metabolite interference with maturation of human monocyte-derived dendritic cells
J. Leukoc. Biol.,
February 1, 2002;
71(2):
238 - 246.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Parlato, S. M. Santini, C. Lapenta, T. Di Pucchio, M. Logozzi, M. Spada, A. M. Giammarioli, W. Malorni, S. Fais, and F. Belardelli
Expression of CCR-7, MIP-3beta , and Th-1 chemokines in type I IFN-induced monocyte-derived dendritic cells: importance for the rapid acquisition of potent migratory and functional activities
Blood,
November 15, 2001;
98(10):
3022 - 3029.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. T. Semnani, H. Sabzevari, R. Iyer, and T. B. Nutman
Filarial Antigens Impair the Function of Human Dendritic Cells during Differentiation
Infect. Immun.,
September 1, 2001;
69(9):
5813 - 5822.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. S. Akimov and A. M. Belkin
Cell surface tissue transglutaminase is involved in adhesion and migration of monocytic cells on fibronectin
Blood,
September 1, 2001;
98(5):
1567 - 1576.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Lehner, T. Felzmann, K. Clodi, and W. Holter
Type I interferons in combination with bacterial stimuli induce apoptosis of monocyte-derived dendritic cells
Blood,
August 1, 2001;
98(3):
736 - 742.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Ito, R. Amakawa, M. Inaba, S. Ikehara, K. Inaba, and S. Fukuhara
Differential Regulation of Human Blood Dendritic Cell Subsets by IFNs
J. Immunol.,
March 1, 2001;
166(5):
2961 - 2969.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Zou, J. Borvak, F. Marches, S. Wei, P. Galanaud, D. Emilie, and T. J. Curiel
Macrophage-Derived Dendritic Cells Have Strong Th1-Polarizing Potential Mediated by {beta}-Chemokines Rather Than IL-12
J. Immunol.,
October 15, 2000;
165(8):
4388 - 4396.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
