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Molecular analysis of infant acute lymphoblastic leukemia: MLL gene
rearrangement and reverse transcriptase-polymerase chain reaction for t(4;
11)(q21; q23)
JM Hilden, JL Frestedt, RO Moore, NA Heerema, DC Arthur, GH Reaman and JH Kersey
University of Minnesota, Children's National Medical Center, Minneapolis
55455, USA.
Molecular techniques to detect MLL (11q23) and AF-4 (4q21) gene
rearrangements are being evaluated for use in stratification of patients
into prognostic groups. We studied 15 cases of infant acute lymphoblastic
leukemia (ALL) with Southern blotting for MLL gene rearrangement and
reverse transcriptase-polymerase chain reaction (RT- PCR) for t(4;11)
fusion transcripts and compared the results to cytogenetic and clinical
data. Our results indicate that classic t(4;11)(q21;q23) translocations are
detected by RT-PCR; however, unusual 4;11 translocations still require
additional investigation. We also extended and updated our original study
of MLL gene rearrangement in infant ALL to 40 patients with longer
follow-up and show that the group with germline configuration of the MLL
gene continues to have an excellent outcome. The results of salvage therapy
(bone marrow transplantation or chemotherapy) suggest that transplant may
show advantage. Preliminary results of the use of RT-PCR to assess minimal
disease are also reported.
Volume 86,
Issue 10,
pp. 3876-3882,
11/15/1995
Copyright © 1995 by The American Society of Hematology
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