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Analyses of thrombocytopenia in idiopathic thrombocytopenic purpura- prone
mice by platelet transfer experiments between (NZW x BXSB)F1 and normal
mice
H Mizutani, T Furubayashi, A Kuriu, H Take, Y Tomiyama, H Yoshida, Y Nakamura, M Inaba, Y Kurata and T Yonezawa
Second Department of Internal Medicine, Osaka University Medical School,
Japan.
Male (NZW x BXSB) F1 (W/B F1) mice, which develop lupus nephritis,
myocardial infarction, and thrombocytopenia, showed reduced platelet
lifespan (PLS) and increased platelet-associated antibody (PAA) values.
There were statistically significant correlations between the increase in
PAA values and either the reduction in PLS or the decrease in platelet
counts. This and the results of platelet transfer experiments between old
male W/B F1 mice and either female W/B F1 or normal BALB/c mice indicate
that PAAs on the platelet surface play a crucial role in the destruction of
platelets in W/B F1 mice. The mechanism of thrombocytopenia observed here
appears similar to that of human idiopathic thrombocytopenic purpura (ITP).
Therefore, we think that W/B F1 mice are a potentially useful animal model
for investigating the effectiveness and mode of action of therapeutic
agents in human ITP, and that they may provide additional information on
the basic mechanisms of this autoimmune phenomenon.
Volume 75,
Issue 9,
pp. 1809-1812,
05/01/1990
Copyright © 1990 by The American Society of Hematology
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