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An additional breakpoint region in the BCL-1 locus associated with the
t(11;14)(q13;q32) translocation of B-lymphocytic malignancy
TC Meeker, JC Grimaldi, R O'Rourke, E Louie, G Juliusson and S Einhorn
Department of Medicine, University of California, San Francisco.
The t(11;14)(q13;q32) translocation is associated with human B- lymphocytic
malignancy. This translocation divides the IgH locus on chromosome 14q32
and may activate a postulated proto-oncogene, bcl-1, located on chromosome
11q13. Two samples of chronic lymphocytic leukemia with the
t(11;14)(q32;q13) translocation were studied. The break in one sample was
shown to join Jh sequences with the previously described bcl-1 major
translocation cluster. DNA blots of the second sample suggested that Jh
sequences were joined to a different breakpoint region on chromosome 11.
This translocation was cloned and found to link the human Jh3 region and a
new breakpoint region 63 kb telomeric of the major translocation cluster.
This translocation occurred in part as the result of an aberrant D-J
recombination. Recurrent translocations human B-lymphocytic malignancy. The
definition of a new breakpoint region may aid the identification of the
postulated bcl-1 gene.
Volume 74,
Issue 5,
pp. 1801-1806,
10/01/1989
Copyright © 1989 by The American Society of Hematology
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