Osmotic fragility of peripheral blood lymphocytes in chronic lymphatic
leukemia and malignant lymphoma
P Resnitzky and N Reichman
The osmotic fragility (OF) of peripheral blood lymphocytes from patients
with chronic lymphatic leukemia (CLL) and non-Hodgkin malignant lymphoma
(ML) was investigated employing an automatic recording method and compared
with that of lymphocytes from healthy subjects and from patients suffering
from various non-neoplastic diseases. The curves from CLL and ML showed a
pattern of increased lymphocyte OF compared with those of the two control
groups, and the difference was statistically significant ( less than
0.001). In CLL the increase in OF was more pronounced than in ML, and the
shape of the curve was different from that in the other groups. The
employment of peripheral blood lymphocyte OF as an additional diagnostic
parameter in the diagnosis of CLL and ML is suggested.
Volume 51,
Issue 4,
pp. 645-651,
04/01/1978
Copyright © 1978 by The American Society of Hematology
