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Blood, 15 December 2005, Vol. 106, No. 13, pp. 4287-4293. Prepublished online as a Blood First Edition Paper on August 25, 2005; DOI 10.1182/blood-2004-09-3620. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-09-3620v1 106/13/4287    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Mathas, S. Articles by Dörken, B. Search for Related Content PubMed PubMed Citation Articles by Mathas, S. Articles by Dörken, B. Related Collections Neoplasia Apoptosis Gene Expression Related Letter in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA Elevated NF-B p50 complex formation and Bcl-3 expression in classical Hodgkin, anaplastic large-cell, and other peripheral T-cell lymphomas Stephan Mathas, Korinna Jöhrens, Stefan Joos, Andreas Lietz, Franziska Hummel, Martin Janz, Franziska Jundt, Ioannis Anagnostopoulos, Kurt Bommert, Peter Lichter, Harald Stein, Claus Scheidereit, and Bernd Dörken From the Max-Delbrück-Center for Molecular Medicine; Hematology, Oncology and Tumorimmunology, Charité, Medical University Berlin, Campus Virchow-Klinikum; the Institute for Pathology, Charité, Medical University Berlin, Campus Benjamin Franklin, Berlin, Germany; and the German Cancer Research Center (B060), Heidelberg, Germany. Transcription factor nuclear factor kappa B (NF-B) plays a central role in the pathogenesis of classical Hodgkin lymphoma (cHL). In anaplastic large-cell lymphomas (ALCLs), which share molecular lesions with cHL, the NF-B system has not been equivalently investigated. Here we describe constitutive NF-B p50 homodimer [(p50)2] activity in ALCL cells in the absence of constitutive activation of the IB kinase (IKK) complex. Furthermore, (p50)2 contributes to the NF-B activity in Hodgkin/Reed-Sternberg (HRS) cells. Bcl-3, which is an inducer of nuclear (p50)2 and is associated with (p50)2 in ALCL and HRS cell lines, is abundantly expressed in ALCL and HRS cells. Notably, a selective overexpression of Bcl-3 target genes is found in ALCL cells. By immunohistochemical screening of 288 lymphoma cases, a strong Bcl-3 expression in cHL and in peripheral T-cell non-Hodgkin lymphoma (T-NHL) including ALCL was found. In 3 of 6 HRS cell lines and 25% of primary ALCL, a copy number increase of the BCL3 gene locus was identified. Together, these data suggest that elevated Bcl-3 expression has an important function in cHL and peripheral T-NHL, in particular ALCL. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Letter in Blood Online: Chromosomal rearrangements involving the BCL3 locus are recurrent in classical Hodgkin and peripheral T-cell lymphoma Jose I. Martin-Subero, Iwona Wlodarska, Christian Bastard, Jean-Michel Picquenot, Jorge Höppner, Maciej Giefing, Wolfram Klapper, Reiner Siebert, Stephan Mathas, Stefan Joos, Harald Stein, and Bernd Dörken Blood 2006 108: 401-403. [Full Text] [PDF] This article has been cited by other articles: S.-H. Kuo, P.-Y. Yeh, L.-T. Chen, M.-S. Wu, C.-W. Lin, K.-H. Yeh, Y.-S. Tzeng, J.-Y. Chen, P.-N. Hsu, J.-T. Lin, et al. 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Aggarwal Nuclear Factor-{kappa}B Activation: From Bench to Bedside Experimental Biology and Medicine, January 1, 2008; 233(1): 21 - 31. [Abstract] [Full Text] [PDF] R. Dai, R. A. Phillips, and S. A. Ahmed Despite Inhibition of Nuclear Localization of NF-{kappa}B p65, c-Rel, and RelB, 17-beta Estradiol Up-Regulates NF-{kappa}B Signaling in Mouse Splenocytes: The Potential Role of Bcl-3 J. Immunol., August 1, 2007; 179(3): 1776 - 1783. [Abstract] [Full Text] [PDF] C. Van Waes Nuclear Factor-{kappa}B in Development, Prevention, and Therapy of Cancer Clin. Cancer Res., February 15, 2007; 13(4): 1076 - 1082. [Abstract] [Full Text] [PDF] A. Chiu, W. Xu, B. He, S. R. Dillon, J. A. Gross, E. Sievers, X. Qiao, P. Santini, E. Hyjek, J.-w. Lee, et al. Hodgkin lymphoma cells express TACI and BCMA receptors and generate survival and proliferation signals in response to BAFF and APRIL Blood, January 15, 2007; 109(2): 729 - 739. [Abstract] [Full Text] [PDF] J. I. Martin-Subero, W. Klapper, A. Sotnikova, E. Callet-Bauchu, L. Harder, C. Bastard, R. Schmitz, S. Grohmann, J. Hoppner, J. Riemke, et al. Chromosomal Breakpoints Affecting Immunoglobulin Loci Are Recurrent in Hodgkin and Reed-Sternberg Cells of Classical Hodgkin Lymphoma Cancer Res., November 1, 2006; 66(21): 10332 - 10338. [Abstract] [Full Text] [PDF] K. Gao, D. L. Dai, M. Martinka, and G. Li Prognostic Significance of Nuclear Factor-{kappa}B p105/p50 in Human Melanoma and Its Role in Cell Migration. Cancer Res., September 1, 2006; 66(17): 8382 - 8388. [Abstract] [Full Text] [PDF] A. Bauer, A. Villunger, V. Labi, S. F. Fischer, A. Strasser, H. Wagner, R. M. Schmid, and G. Hacker The NF-{kappa}B regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells PNAS, July 18, 2006; 103(29): 10979 - 10984. [Abstract] [Full Text] [PDF] J. I. Martin-Subero, I. Wlodarska, C. Bastard, J.-M. Picquenot, J. Hoppner, M. Giefing, W. Klapper, R. Siebert, S. Mathas, S. Joos, et al. Chromosomal rearrangements involving the BCL3 locus are recurrent in classical Hodgkin and peripheral T-cell lymphoma. Blood, July 1, 2006; 108(1): 401 - 403. [Full Text] [PDF] E. Jacobsen Anaplastic Large-Cell Lymphoma, T-/Null-Cell Type Oncologist, July 1, 2006; 11(7): 831 - 840. [Abstract] [Full Text] [PDF]

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