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Blood, 15 September 2004, Vol. 104, No. 6, pp. 1894-1897. Prepublished online as a Blood First Edition Paper on April 29, 2004; DOI 10.1182/blood-2004-02-0508. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-02-0508v1 104/6/1894    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Adams, K. M. Articles by Nelson, J. L. Search for Related Content PubMed PubMed Citation Articles by Adams, K. M. Articles by Nelson, J. L. Related Collections Immunobiology Transplantation Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION Risk factors for syngeneic graft-versus-host disease after adult hematopoietic cell transplantation Kristina M. Adams, Leona A. Holmberg, Wendy Leisenring, Alexander Fefer, Katherine A. Guthrie, Tracy S. Tylee, George B. McDonald, William I. Bensinger, and J. Lee Nelson From the Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA; and the Department of Obstetrics and Gynecology, Division of Medical Oncology, School of Medicine, Division of Gastroenterology, and Division of Rheumatology, University of Washington, Seattle, WA. Syngeneic graft-versus-host disease (sGVHD) has been described after hematopoietic cell transplantation (HCT) but remains poorly defined. We retrospectively reviewed adult syngeneic HCTs at our center (1980-2002) for sGVHD to investigate incidence, morbidity, and risk factors with a primary focus on parity. Among 119 transplantations, there were 21 cases of biopsy-proven sGVHD. The cumulative incidence was 18%, with multiorgan involvement in 6 cases and 1 death. sGVHD was more frequent when the donor was parous (32%) than nulliparous (9%) or male (13%; P = .03) and when the recipient was parous (31%) than nulliparous (7%) or male (13%; P = .02). Other univariable risk factors included older age (P < .01), busulfan/melphalan/thiotepa conditioning (P < .01), interleukin-2 (P = .02), HLA-A26 (P = .03), and more recent transplantation year (P < .01). Overall, risk factors were similar to those described in GVHD. Although an independent effect of parity could not be completely separated from other factors, donor and recipient pregnancy history merits further investigation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: L. Fouillard, M. Labopin, A. Gratwohl, E. Gluckman, F. Frassoni, D. W. Beelen, R. Willemze, E. Montserrat, D. Blaise, A. I. Atienza, et al. Results of syngeneic hematopoietic stem cell transplantation for acute leukemia: risk factors for outcomes of adults transplanted in first complete remission Haematologica, June 1, 2008; 93(6): 834 - 841. [Abstract] [Full Text] [PDF] H. C. Fung, M. A. Higman, and K. van Besien Stem cell transplantation ASH Self-Assessment Program, January 1, 2007; 2007(1): 328 - 360. [Full Text] [PDF] L. H. S. Tomas, F. R. Loberiza Jr, J. P. Klein, P. M. Layde, R. J. Lipchik, J. D. Rizzo, C. N. Bredeson, and M. M. Horowitz Risk Factors for Bronchiolitis Obliterans in Allogeneic Hematopoietic Stem-Cell Transplantation for Leukemia Chest, July 1, 2005; 128(1): 153 - 161. [Abstract] [Full Text] [PDF]

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