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Blood, 15 November 2004, Vol. 104, No. 10, pp. 3153-3160.
Prepublished online as a Blood First Edition Paper on July 29, 2004; DOI 10.1182/blood-2004-03-0809.
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HEMATOPOIESIS
Erythroblasts secrete the nonclassical HLA-G molecule from primitive to definitive hematopoiesis
Catherine Menier,
Michèle Rabreau,
Jean-Claude Challier,
Magali Le Discorde,
Edgardo D. Carosella, and
Nathalie Rouas-Freiss
From the Service de Recherches en Hémato-Immunologie, Hôpital Saint Louis, Paris, France; the Institut d'Histo-Cyto-Pathologie, Le Bouscat, France; the Laboratoire de Foetopathologie, Bordeaux, France; and the Physiopathologie de l'Implantation et du Developpement, Université Pierre et Marie Curie, Paris, France.
The initial steps of primitive hematopoiesis and endothelial vascular formation in the human embryo remain to be defined. Here, we report the identification of a novel marker, namely the nonclassical HLA-G class I molecule, which targets both primitive erythroid cells of the yolk sac and endothelial cells from developing vessels. Moreover, HLA-G was present in its soluble form in the erythropoietic lineage in all organs sustaining primitive to definitive erythropoiesis (ie, aorta-gonad-mesonephros, liver, spleen, and bone marrow). The alternatively spliced transcript coding the soluble HLA-G5 molecule was detected in erythroid cells. The corresponding intron 4–retaining 37-kDa HLA-G5 isoform was secreted from the erythroid progenitor stage to the reticulocyte but was lost in mature erythrocytes and in endothelial cells from differentiated vessels. This study constitutes the first description of an HLA class I antigen expression on the primitive erythroid lineage and provides a way of seeking both primitive and definitive erythropoiesis using HLA-G5. This new marker, previously known by its immunotolerogeneic properties, may be involved in erythroid differentiation, angiogenesis, or both.
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