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Blood, 1 December 2003, Vol. 102, No. 12, pp. 3871-3879. Prepublished online as a Blood First Edition Paper on August 21, 2003; DOI 10.1182/blood-2003-06-1841. This Article Full Text Full Text (PDF) Supplemental Data All Versions of this Article: 2003-06-1841v1 102/12/3871    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Savage, K. J. Articles by Shipp, M. A. Search for Related Content PubMed PubMed Citation Articles by Savage, K. J. Articles by Shipp, M. A. Related Collections Neoplasia Apoptosis Plenary Papers Signal Transduction Gene Expression Genomics Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  PLENARY PAPERS The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma Kerry J. Savage, Stefano Monti, Jeffery L. Kutok, Giorgio Cattoretti, Donna Neuberg, Laurence de Leval, Paul Kurtin, Paola Dal Cin, Christine Ladd, Friedrich Feuerhake, Ricardo C. T. Aguiar, Sigui Li, Gilles Salles, Francoise Berger, Wen Jing, Geraldine S. Pinkus, Thomas Habermann, Riccardo Dalla-Favera, Nancy Lee Harris, Jon C. Aster, Todd R. Golub, and Margaret A. Shipp From the Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA; Whitehead Institute/Massachusetts Institute of Technology (MIT) Center for Genome Research, Cambridge, MA; Department of Pathology, Brigham and Women's Hospital, Boston, MA; Institute for Cancer Genetics, Columbia University, New York, NY; Department of Biostatistical Science, Dana-Farber Cancer Institute, Boston, MA; Department of Pathology, Massachusetts General Hospital, Boston, MA; Department of Pathology, Mayo Clinic, Rochester, MN; Hematology Department, Centre Hospitalier Lyon-Sud, Lyon, France; Department of Pathology, Centre Hospitalier Lyon-Sud, Lyon, France; Division of Hematology and Department of Medicine, Mayo Clinic, Rochester, MN; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Howard Hughes Medical Institute, Boston, MA. Mediastinal large B-cell lymphoma (MLBCL) is a recently identified subtype of diffuse large B-cell lymphoma (DLBCL) that characteristically presents as localized tumors in young female patients. Although MLBCL has distinctive pathologic features, it clinically resembles the nodular sclerosis subtype of classical Hodgkin lymphoma (cHL). To elucidate the molecular features of MLBCL, we compared the gene expression profiles of newly diagnosed MLBCL and DLBCL and developed a classifier of these diseases. MLBCLs had low levels of expression of multiple components of the B-cell receptor signaling cascade, a profile resembling that of Reed-Sternberg cells of cHL. Like cHLs, MLBCLs also had high levels of expression of the interleukin-13 (IL-13) receptor and downstream effectors of IL-13 signaling (Janus kinase-2 [JAK2] and signal transducer and activator of transcription-1 [STAT1]), tumor necrosis factor (TNF) family members, and TNF receptor-associated factor-1 (TRAF1). Increased expression of STAT1 and TRAF1 in MLBCL was confirmed by immunohisto-chemistry. Given the TRAF1 expression and known link to nuclear factor–B (NF- B), MLBCLs were also evaluated for nuclear translocation of c-REL protein. In almost all cases, c-REL was localized to the nucleus, consistent with activation of the NF-B pathway. These studies identify a molecular link between MLBCL and cHL and a shared survival pathway. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Mediastinal B-cell lymphoma, classical Hodgkin disease, and the winds of change Peter Möller Blood 2003 102: 3855. [Full Text] [PDF] This article has been cited by other articles: E. S. Jaffe, N. L. Harris, H. Stein, and P. G. Isaacson Classification of lymphoid neoplasms: the microscope as a tool for disease discovery Blood, December 1, 2008; 112(12): 4384 - 4399. [Abstract] [Full Text] [PDF] S. J. Rodig, J. Ouyang, P. Juszczynski, T. Currie, K. 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